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The oral-gut axis thus serves as a critical mediator in systemic inflammation and disease progression, with specific microbial taxa offering potential biomarkers for early detection, as seen in oral cancer where Haemophilus parainfluenzae and Rothia mucilaginosa are malignancy-associated (Nayyar et al., 2025)

10.1242/dev.055665 Development 159 TaiW.WuW.WangL.NiH.ChenC.YangJ.et al (2021)

In particular, the insulin hexamers are inactive and cannot perform their natural biological function in this state

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